■ 產(chǎn)品介紹
手性有機小分子催化劑因具有反應(yīng)條件溫和、環(huán)境友好、催化劑易于回收利用、符合綠色化學(xué)的要求等優(yōu)點，成為近年來不對稱催化領(lǐng)域發(fā)展起來的一個研究熱點。其中，手性環(huán)胍類有機小分子催化劑可用于不對稱的Michael 加成反應(yīng)、Mannich反應(yīng)、脫羧反應(yīng)、胺化反應(yīng)及炔烴的手性連烯重排反應(yīng)等等，并可實現(xiàn)良好收率和立體選擇性，充分顯示了手性環(huán)胍小分子催化劑在不對稱反應(yīng)中的巨大潛力。
產(chǎn)品性質(zhì)穩(wěn)定，易于儲存；
反應(yīng)條件溫和，反應(yīng)易于操作；
反應(yīng)底物范圍廣，可催化多種反應(yīng)類型；
催化劑無金屬殘留，可用于制藥或香精香料生產(chǎn)；
高度優(yōu)勢的產(chǎn)品價格，齊全的包裝規(guī)格，國內(nèi)現(xiàn)貨量充足。
■ 手性五元二環(huán)胍
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產(chǎn)品編號
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產(chǎn)品名稱
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結(jié)構(gòu)式
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CAS
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包裝
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(2S,6S)-雙芐基五元二環(huán)胍
(2S,6S)-2,6-Di-benzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole, 98%
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100 mg
500 mg
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(2S,6S)-雙叔丁基五元二環(huán)胍
(2S,6S)-2,6-Di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole, 98%
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100 mg
500 mg
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■ 產(chǎn)品技術(shù)應(yīng)用
1. Biomimetic Enantioselective Decarboxylative Reactions catalysed by chiral bicyclic guanidine;
2. Bicyclic guanidine-catalyzed enantioselective Phospha-Michael reaction;
3. Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-Aryl Alkylidene-Succinimides;
4. Enantioselective Protonation Catalyzed by a Chiral Bicyclic Guanidine;
5. Chiral bicyclic guanidine catalysed Mannich reaction;
6. Enantiodivergent and g-Selective Asymmetric Allylic Amination;
7. Enantioselective Synthesis of Chiral Allenoates by Guanidine-Catalyzed Isomerization of 3-Alkynoates.
Ref.:
[1]. Chem. Eur. J. 2011, 17, 8363 - 8370;
[2]. Chemical Commununications, 2007, 47, 5058-5060;
[3]. Chem. Eur. J. 2010, 16, 12534 - 12537;
[4]. Angew. Chem. Int. Ed. 2008, 47, 5641 - 5645;
[5]. a). Chem. Eur. J. 2011, 17, 3571 - 3574; b). Chem. Eur. J. 2010, 16, 779 -782;
[6]. Angew. Chem. Int. Ed. 2012, 51, 1 - 6;
[7]. J. Am. Chem. Soc. 2009, 131, 7212 - 7213.
■ 其它手性有機小分子催化劑
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產(chǎn)品編號
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產(chǎn)品名稱
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結(jié)構(gòu)式
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CAS
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包裝
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(S)-(+)-2-(苯胺甲基)吡咯烷
(S)-(+)-2-(Anilinomethyl)pyrrolidine, 97%
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250 mg
1 g
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L-氮雜環(huán)丁烷-2-羧酸
L-Azetidine-2-carboxylic acid, 98%
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50 mg
250 mg
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(S)-α,α-雙[3,5-雙(三氟甲基)苯基]-2-吡咯烷甲醇三甲基硅基醚
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether, 95%
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250 mg
1 g
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α,α-二苯基-N-甲基-D-脯氨醇
α,α-Diphenyl-N-methyl-D-prolinol, 98% [ee: 98%]
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250 mg
1 g
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α,α-二苯基-N-甲基-L-脯氨醇
α,α-Diphenyl-N-methyl-L-prolinol, 97%
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250 mg
1 g
5 g
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(R)-(+)-2-(二苯基甲基)吡咯烷
(R)-(+)-2-(Diphenylmethyl)pyrrolidine, 97%
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250 mg
1 g
5 g
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(S)-2-二苯基甲基吡咯烷
(S)-2-Diphenylmethylpyrrolidine, 97%
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250 mg
1 g
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(R)-(+)-α,α-二苯基脯氨醇
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol, 98%
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250 mg
1 g
5 g
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(S)-(-)-α,α-二苯基-2-脯氨醇
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol, 98%
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500 mg
1 g
5 g
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α-甲基-L-脯氨酸
α-Methyl-L-proline, 98%
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250 mg
1 g
5 g
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L-脯氨酸
L-Proline, 99%
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25 g
100 g
500 g
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(S)-(+)-1-(2-吡咯烷甲基)吡咯烷
(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine, 98%
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250 mg
1 g
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N-[(2S)-2-吡咯烷甲基]-三氟甲磺酰胺
N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide, 98.5% [ee:98.5%]
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100 mg
500 mg
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(S)-(-)-5-(吡咯烷-2-基)-1H-四唑
(S)-(-)-5-(2-Pyrrolidinyl)-1H-tetrazole, 98%
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100 mg
500 mg
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L-4-羧基噻唑烷
L-4-Thiazolidinecarboxylic acid, 98%
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5 g
25 g
100 g
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