BINAP由于空間位阻大、雙萘環(huán)的消旋障礙高，限制了連接兩萘環(huán)的化學(xué)鍵自由旋轉(zhuǎn)，可與釕、銠和鈀配合物催化劑協(xié)同進(jìn)行對(duì)映選擇性反應(yīng)。BINAP金屬配合物催化劑在烯烴、酮、亞胺的不對(duì)稱氫化、關(guān)環(huán)以及C-C鍵形成等反應(yīng)中應(yīng)用廣泛。BINAP配體及BINAP Ru Cymene催化劑、BINAP Ru Dimer催化劑、BINAP Ru Acetate催化劑和BINAP Ru Diammine 催化劑，催化活性高（TOF可達(dá)30,000以上），對(duì)映選擇性好（ee＞95%，收率最高可達(dá)99%），供貨穩(wěn)定，并可提供公斤級(jí)大包裝定制，可滿足科研和生產(chǎn)的不同需求。
BINAP 配體
Technical Notes:
1. Ligand (BINAP) employed in the rhodium-catalyzed asymmetric 1,4-addition of arylalanes on trisubstituted enones.
2. Ligand (TolBINAP) used in the copper-catalyzed asymmetric synthesis of cyclopropanes via tandem conjugate addition and intramolecular enolate trapping.
3. Ligand (XylBINAP) used in the asymmetric reduction of ketone via ruthenium-catalyzed transfer hydrogenation.
4. Ligand (H8-BINAP) for palladium-catalyzed enantioselective hydrogenation of substituted indoles.
References:
1. Angew. Chem. Int. Ed., 2010, 49, 7769.
2. J. Am. Chem. Soc., 2010, 132, 14349.
3. J. Am. Chem. Soc., 2011, 133, 10696.
4. J. Am. Chem. Soc., 2010, 132, 8909.
96-6950 Takasago BINAP Ligand Kit
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15-0150
(R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl, 98%
(R)-(+)-BINAP [76189-55-4]
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15-0152
(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl, 98%
(R)-(+)-TolBINAP[99646-28-3]
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15-0476
(R)-(+)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl, 98%
(R)-(+)-XylBINAP[137219-86-4]
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15-0151
(S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl, 97%
(S)-(-)-BINAP[76189-56-5]
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15-0153
(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl, 98%
(S)-(-)-TolBINAP[100165-88-6]
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15-0477
(S)-(-)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl, 98% (S)-(-)-XylBINAP
[135139-00-3]
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BINAP 釕類催化劑
Technical Note:
1. This catalyst has shown to effect the highly enantioselective hydrogenation of functionalized ketones where the substituents
are dialkylamino, hydoxy, siloxy, carbonyl, ester, amide or thioester.
2. The ruthenium catalyzed hydrogenation of aryl propenoic acid to produce the drug Ibuprofen.
3. Catalyst system that exhibits high catalytic activity and enantioselectivity in the hydrogenation of enamines.
References:
1. Tetrahedron Lett., 2008, 49, 4836.
2. J. Org. Chem., 1996, 61, 5510.
3. Topics Organometal. Chem. 2004, 6, 63
4. J. Org. Chem., 1994, 59, 297.
96-6951 Takasago BINAP Ru Cymene Catalyst Kit
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44-0084
Chloro[(R)-(+)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl](p-cymene) ruthenium(II) chloride
[RuCl(p-cymene)((R)-binap)]Cl[145926-28-9]
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44-0088
Chloro[(R)-(+)-2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl](p-cymene) ruthenium(II) chloride
[RuCl(p-cymene) ((R)-tolbinap)]Cl [131614-43-2]
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44-0092
Chloro{(R)-(+)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride
[RuCl(p-cymene)((R)-xylbinap)]Cl[944451-24-5]
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44-0086
Chloro[(S)-(-)-2,2'-bis(diphenyl-phosphino)-1,1'-binaphthyl](p-cymene) ruthenium(II) chloride
[RuCl(p-cymene) ((S)-binap)]Cl [130004-33-0]
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44-0089
Chloro[(S)-(-)-2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl](p-cymene)ruthenium(II) chloride
[RuCl(p-cymene)((S)-tolbinap)]Cl [228120-95-4]
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44-0093
Chloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}(p-cymene)ruthenium(II) chloride
[RuCl(p-cymene) ((S)-xylbinap)]Cl [944451-25-6]
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96-6952 Takasago BINAP Ru Dimer Catalyst Kit
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44-0510
Dimethylammonium dichlorotri(μ-chloro)bis[(R)-(+)-2,2'-bis (diphenylphosphino)-1,1'-binaphthyl]diruthenate(II)
[NH2Me2][{RuCl((R)-binap)}2(μ-Cl)3][199684-47-4]
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44-0512
Dimethylammonium dichlorotri(μ-chloro)bis[(R)-(+)-2,2'-bis (di-ptolylphosphino)-1,1'-binaphthyl]diruthenate(II)
[NH2Me2][{RuCl((R)-tolbinap)}2(μ-Cl)3][749935-02-2]
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44-0514
Dimethylammonium dichlorotri(μ-chloro)bis{(R)-(+)-2,2'-bis [di(3,5-xylyl)phosphino]-1,1'-binaphthyl}diruthenate(II)
[NH2Me2][{RuCl((R)-xylbinap)}2(μ-Cl)3][944451-08-5]
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44-0511
Dimethylammonium dichlorotri(μ-chloro)bis[(S)-(-)-2,2'-bis (diphenylphosphino)-1,1'-binaphthyl]diruthenate(II)
[NH2Me2][{RuCl((S)-binap)}2(μ-Cl)3][199541-17-8]
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44-0513
Dimethylammonium dichlorotri(μ-chloro)bis[(S)-(-)-2,2'-bis (di-ptolylphosphino)-1,1'-binaphthyl]diruthenate(II)
[NH2Me2][{RuCl((S)-tolbinap)}2(μ-Cl)3][309735-86-2]
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44-0515
Dimethylammonium dichlorotri(μ-chloro)bis{(S)-(-)-2,2'-bis [di(3,5-xylyl)phosphino]-1,1'-binaphthyl}diruthenate(II)
[NH2Me2][{RuCl((S)-xylbinap)}2(μ-Cl)3][944451-10-9]
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96-6953 Takasago BINAP Ru Acetate Catalyst Kit
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44-0152
Diacetate[(R)-(+)-2,2'-bis(di-phenylphosphino)-1,1'-binaphthyl] ruthenium(II)
Ru(OAc)2[(R)-binap][325146-81-4]
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44-0162
Diacetato[(R)-(+)-2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl] ruthenium(II)
Ru(OAc)2[(R)-tolbinap][116128-29-1]
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44-0164
Diacetato{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}ruthenium(II)
Ru(OAc)2[(R)-xylbinap] [374067-50-2]
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44-0153
Diacetato[(S)-(-)-2,2'-bis(di-phenylphosphino)-1,1'-binaphthyl] ruthenium(II)
Ru(OAc)2[(S)-binap][261948-85-0]
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44-0163
Diacetato[(S)-(-)-2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl] ruthenium(II)
Ru(OAc)2[(S)-tolbinap][106681-15-6]
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44-0165
Diacetato{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}ruthenium(II)
Ru(OAc)2[(S)-xylbinap] [374067-49-9]
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96-6954 Takasago BINAP Ru Diammine Catalyst Kit
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44-0212
Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
RuCl2[(R)-xylbinap][(R)-daipen][220114-32-9]
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44-0226
Dichloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl0}[(1R,2R)-(+)-1,2-diphenylethylenediamine]ruthenium(II)
RuCl2[(R)-xylbinap][(R,R)-dpen][220114-38-5]
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44-0217
Chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1-(4-methoxyphenyl)-1’-(4-methoxyphenyl-kC)-3-methyl-1,2-butanediamine]ruthenium(II)
(R)-RUCY™-XylBINAP
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44-0213
Dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]ruthenium(II)
RuCl2[(S)-xylbinap][(S)-daipen][220114-01-2]
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44-0224
Dichloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(1S,2S)-(-)-1,2-diphenylethylenediamine]ruthenium(II)
RuCl2[(S)-xylbinap][(S,S)-dpen][220114-03-4]
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44-0218
Chloro{(S)-(-)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2S)-(+)-1-(4-methoxyphenyl)-1’-(4-methoxyphenyl-kC)-3-methyl-1,2-butanediamine]ruthenium(II)
(S)-RUCY™-XylBINAP [1312713-89-5]
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注：1、以上產(chǎn)品均為Takasago®專利產(chǎn)品；
2、可提供大包裝定制服務(wù)。