百靈威專業(yè)提供Echelon品牌LPA及Autotaxin系列產(chǎn)品。Echelon是美國(guó)著名的生化產(chǎn)品供應(yīng)商，專注于脂類（Lipid）研究領(lǐng)域，為廣大新藥研發(fā)、糖尿病及癌癥等疾病診斷科研工作者提供最先進(jìn)的研究工具。
溶血磷脂酸(LPA)由血小板、成纖維細(xì)胞、癌細(xì)胞和脂肪細(xì)胞等分泌，是一種多功能的“磷脂信使”，它通過 G蛋白偶聯(lián)受體引起多種生物學(xué)效應(yīng)，對(duì)細(xì)胞的生長(zhǎng)、增殖、分化及細(xì)胞內(nèi)信息傳遞等產(chǎn)生影響,在多種重大疾病如心腦血管病、腎病、腫瘤的發(fā)生和發(fā)展中起著重要作用。
Autotaxin(ATX)是一個(gè)分泌型糖蛋白，具有溶血磷脂酶D(lysoPLD)活性，能夠以溶血磷脂酰膽堿(lysophosphatidylcholjne,LPC)為底物催化生成溶血磷脂酸(lysophosphatidic acid,LPA)。ATX在很多腫瘤細(xì)胞中都有高表達(dá),在腫瘤的發(fā)生、發(fā)展過程中有著重要作用。
Echelon為L(zhǎng)PA及ATX研究者提供從Autotaxin Enzyme、酶抑制劑、底物到試劑盒的全套解決方案；同時(shí)采用競(jìng)爭(zhēng)性檢測(cè)手段，非放射性檢測(cè)，比傳統(tǒng)方法更加直接、便捷、高效！
LPA和Autotaxin相關(guān)產(chǎn)品
檢測(cè)試劑盒
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K-2800B
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Lysophosphatidic Acid Competitive ELISA Kit
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Autotaxin Activity Assay
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Autotaxin Inhibitor Screening Kit
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High Throughput Autotaxin Inhibitor Screening Kit
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底物
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1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine
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1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine
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FS-3 (lysoPLD / Autotaxin substrate)
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PLA2 Substrate, DBPC
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酶
抑制劑
溶血磷脂酸（LPA）選擇性配體
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(3S) 1-fluoro-3-hydroxy-4-butyl-1-phosphonate
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2R-OMPT-D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate
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2S-OMPT-L-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate
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Alkyl-OMPT
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(2R) 1,1-difluoro-2-palmitoyloxy<br>-3-phospho propane
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磷脂衍生物
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3,3'-Bisoleoyl-LBPA tetrabutylammonium salt
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Biotinylated Ether C12 Lysobisphosphatidic Acid
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bis(monoacylglyceryl)phosphate
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Ether C12 Lysobisphosphatidic Acid
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Ether C18 Lysobisphosphatidic Acid
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飽和與不飽和的溶血磷脂酸（LPA）
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L-60B16
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Biotin-Labeled Phosphatidylethanol
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D (+)-sn-1-O-arachidonoyl-<br>glyceryl-3-phosphate
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D (+)-sn-1-O-arachidoyl-glyceryl-3-phosphate
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D (+)-sn-1-O-linolenoyl-glyceryl-3-phosphate
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D (+)-sn-1-O-linoleoyl-glyceryl-3-phosphate
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D (+)-sn-1-O-oleoyl-glyceryl-3-phosphate
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NBD-Labeled Phosphatidylethanol
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其它相關(guān)產(chǎn)品
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L-sn-1-O-oleyl-glyceryl-3-phosphate
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(2R) 1,1-difluoro-2-palmitoyloxy<br>-3-phospho propane
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(3S) [1,1-difluoro-3,4-bis(oleoyloxy) butyl] phosphonate (XY-14)
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LPA Beads
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Biotin Monolysocardiolipin
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Fluorescein Monolysocardiolipin
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