5-HT（5-Hydroxytryptamine，5-羥色胺）神經(jīng)遞質(zhì)主要分布于松果體和下丘腦，可參與食欲、體溫調(diào)節(jié)，情緒，心血管功能，內(nèi)分泌和抑郁等生理功能的調(diào)節(jié)。5-HT通過激動不同的5-HT受體，可具有不同藥理作用，因此，5-HT受體拮抗劑成為藥物設(shè)計的研究熱點[1][2]。百靈威作為專業(yè)試劑供應(yīng)商，提供多種5-HT受體拮抗劑，為您的科研助力加油！
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產(chǎn)品編號
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中英文名稱
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CAS
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規(guī)格
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384285
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Granisetron hydrochloride, 98%, a serotonin 5-HT3 receptor antagonist
鹽酸格拉司瓊, 98%, 5-HT3受體拮抗劑
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107007-99-8
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200 mg
1 g
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283801
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Ketanserin, 99%, a specific 5-HT2A serotonin receptor antagonist
凱他色林, 99%, 特異性的5-HT2A 5-羥色胺受體拮抗劑
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74050-98-9
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250 mg
1 g
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185928
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Lamotrigine, 98%, Novel anticonvulsant drug for inhibition of 5-HT
拉莫三嗪, 98%, 抑制5-羥色胺(5-HT)吸收
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84057-84-1
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1 g
5 g
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574335
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Mirtazapine, 99%, 5-HT Receptor
米爾塔扎平, 99%, 5-HT受體抑制劑
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85650-52-8
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100 mg
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496697
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Olanzapine, 99%, High affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist
奧氮平, 99%, 5-HT2和D2受體高親和性拮抗劑
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132539-06-1
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1 g
5 g
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977215
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Paliperidone, 99%, potent D2 and 5-HT2A antagonist
帕潘立酮, 99%, 高效D2和5HT2A拮抗劑
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144598-75-4
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10 mg
50 mg
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144809
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Sumatriptan succinate, 98%, 5-HT1 receptor agonist
琥珀酸舒馬曲普坦, 98%, 5-HT1 受體激動劑
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103628-48-4
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100 mg
500 mg
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522188
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Tropisetron monohydrochloride, 99%, 5-HT3 receptor antagonist and α7-nicotinic receptor agonist
鹽酸托烷司瓊, 99%, 5-HT3受體拮抗劑和α7-煙堿受體激動劑
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105826-92-4
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1 g
5 g
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186095
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Ziprasidone hydrochloride monohydrate, 99%, a novel and potent dopamine and serotonin (5-HT) receptor antagonist
齊拉西酮鹽酸鹽一水合物, 99%, 有效的dopamine 和 serotonin (5-HT) receptor的拮抗劑
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138982-67-9
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250 mg
1 g
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Figure1 Figure2
Figure1: Structure of Lamotrigine (185928)[1]
Figure2: Interactions of Lamotrigine(185928) with the binding pocket (subdomain IB)[1]
References
[1] Poureshghi F, Ghandforoushan P, Safarnejad A, et al. Interaction of an antiepileptic drug, lamotrigine with human serum albumin (HSA): Application of spectroscopic techniques and molecular modeling methods[J]. Journal of Photochemistry and Photobiology B: Biology, 2017, 166: 187-192.
[2]Yatham L N, Beaulieu S, Schaffer A, et al. Optimal duration of risperidone or olanzapine adjunctive therapy to mood stabilizer following remission of a manic episode: A CANMAT randomized double-blind trial[J]. Molecular psychiatry, 2016, 21(8): 1050-1056.
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產(chǎn)品編號
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中英文名稱
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CAS
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包裝規(guī)格
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163651
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(+)-Bicuculline, 99.5%, GABAA antagonist
(+)-荷包牡丹堿, 99.5%, GABAA 拮抗劑
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485-49-4
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25 mg
100 mg
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240627
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Candesartan cilexetil, 98%, ATR antagonist
坎地沙坦酯, 98%, ATR 拮抗劑
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145040-37-5
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50 mg
100 mg
500 mg
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410760
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Cyproterone acetate, 98%, an androgen receptor (AR) antagonist
環(huán)丙孕酮醋酸鹽, 98%, 一種雄激素受體拮抗劑
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427-51-0
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50 mg
250 mg
1 g
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195685
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Leuprorelin acetate, 98%, an agonist at pituitary GnRH receptors
醋酸亮丙瑞林, 98%, 一種垂體促性腺激素受體抑制劑
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74381-53-6
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5 mg
25 mg
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408413
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Tropicamide, 99%, potent selective M4 antagonist
托品酰胺, 99%, 有效選擇性M4拮抗劑
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1508-75-4
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10 g
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